Protein profile

PA2558

transporter

Genome: NC_002516.2

Gene: PA2558 Structure source: AlphaFold UniProt Q9I0S6
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Amino acids 230
Annotations 2
Features 26
PDB binders 0
Druggability 0.935

Overview

Basic information about this protein and its source genome.

Accession
PA2558
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2558
Status
annotated
Amino acids
230
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.935
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
31 49 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
99 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
138 230 Gene3D G3DSA:3.30.70.260 -
9 129 Pfam PF02308 MgtC family
9 129 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
126 230 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
53 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 226 PANTHER PTHR33778 PROTEIN MGTC
4 226 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
84 108 PRINTS PR01837 MgtC/SapB protein signature
84 108 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
12 31 PRINTS PR01837 MgtC/SapB protein signature
12 31 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
57 79 PRINTS PR01837 MgtC/SapB protein signature
57 79 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
31 49 PRINTS PR01837 MgtC/SapB protein signature
79 98 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
61 78 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 51 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 78 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 21 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2558
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.935
3 0.627
5 0.231