Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2561
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: ctpH PA2561
Status: annotated
Amino acids: 568
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0010247 The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.631

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MPASPGHRDVLGCLVAACVPVQPGNPSRRSMLQQSLRAQILVLLGGSLAALLLIALACFGSLTGDVRAYRELLGGPVRAAQLIDEANLQFRGQVQEWKNVLLRGRQTEAQTKYWSQFEAQERAVQDILGRLGSVAEGELKDRVERLREEHRRLGTAYRQGRQRFLEAGADPIAGDQAVTGIDRATTAQMQTLRDELHQASDLHSSSISAEARRTMLLGSLVLIGASLAVALLSLWLVNRNLVRPVQRLIEHIAQLSHGDFGERIEIRRKDELGKLALAANTLRDFLVDIFDRLRRSTRDLDSASGSLNAIASLMAAGTREQFSRTDQVATAMQEMSATAQEVARYAGDAARAADEADDSAQRGEDVMEETIRSIGEMRKEIDHTVEVIRQLESDSGRIGKVLDVIRGIAEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAQRTAESIAEIHQIIDTVQNGAVNAARAIESGQSRSEAGAEQVANAGAMLRQITASVESIRDMNRQIATAAEEQTAVAEEISRNLTEIASIASSNQEQVEQTEAASRDLHGLSAQLGDALQRLRA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0010247 The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal.
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records

Show feature table

Start	End	DB	Term	Name
24	38	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
284	568	Gene3D	G3DSA:1.10.287.950	-
242	286	CDD	cd06225	HAMP
236	278	Pfam	PF00672	HAMP domain
236	278	InterPro	IPR003660	HAMP domain
239	568	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
10	18	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
326	386	SMART	SM00304	HAMP_11
326	386	InterPro	IPR003660	HAMP domain
239	291	SMART	SM00304	HAMP_11
239	291	InterPro	IPR003660	HAMP domain
239	291	ProSiteProfiles	PS50885	HAMP domain profile.
39	62	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
19	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
238	283	Gene3D	G3DSA:1.10.8.500	HAMP domain in histidine kinase
215	237	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
110	567	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
259	567	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
296	532	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
296	532	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
238	568	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
433	462	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
433	462	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
320	349	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
320	349	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
352	534	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
352	534	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
333	532	CDD	cd11386	MCP_signal
306	567	SMART	SM00283	MA_2
306	567	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
215	237	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
63	214	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
40	62	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2561	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
13				0.631
11				0.338
6				0.319
12				0.303

PA2561