Protein profile

PA2578

acetyltransferase

Genome: NC_002516.2

Gene: PA2578 Structure source: Experimental + AlphaFold UniProt Q9I0Q8
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Amino acids 186
Annotations 2
Features 9
PDB binders 0
Druggability 0.802

Overview

Basic information about this protein and its source genome.

Accession
PA2578
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2578
Status
annotated
Amino acids
186
Structure source
Experimental + AlphaFold
EC
2.3.1.-
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.802
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
35 149 Pfam PF00583 Acetyltransferase (GNAT) family
35 149 InterPro IPR000182 GNAT domain
11 180 PANTHER PTHR43441 RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE
68 132 CDD cd04301 NAT_SF
12 176 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
12 176 InterPro IPR000182 GNAT domain
1 186 Gene3D G3DSA:3.40.630.30 -
10 179 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
10 179 InterPro IPR016181 Acyl-CoA N-acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3OWC
X-ray 1.90 Å A,B
100.0% 1-186
PDBe RCSB PDBj File
Viewing
AlphaFold PA2578
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.802

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.85 0.582
2 2.28 0.057
3 0.75 0.002