Protein profile

PA2588

transcriptional regulator

Genome: NC_002516.2

Gene: PA2588 Structure source: Experimental + AlphaFold UniProt Q9I0P9
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Amino acids 342
Annotations 4
Features 13
PDB binders 0
Druggability 0.865

Overview

Basic information about this protein and its source genome.

Accession
PA2588
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2588
Status
annotated
Amino acids
342
Structure source
Experimental + AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.865
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
228 336 Gene3D G3DSA:1.10.10.60 -
1 331 PANTHER PTHR47894 HTH-TYPE TRANSCRIPTIONAL REGULATOR GADX
43 198 Pfam PF12625 Arabinose-binding domain of AraC transcription regulator, N-term
43 198 InterPro IPR032687 HTH-type transcriptional regulator AraC-type, N-terminal
251 328 Pfam PF12833 Helix-turn-helix domain
251 328 InterPro IPR018060 DNA binding HTH domain, AraC-type
232 329 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
232 329 InterPro IPR018060 DNA binding HTH domain, AraC-type
282 302 Coils Coil Coil
245 327 SMART SM00342 aracneu4
245 327 InterPro IPR018060 DNA binding HTH domain, AraC-type
280 329 SUPERFAMILY SSF46689 Homeodomain-like
280 329 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5CHH
X-ray 1.85 Å A
99.7% 2-342
PDBe RCSB PDBj File
Viewing
AlphaFold PA2588
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.865
5 0.203

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.79 0.699
2 4.0 0.159
3 3.33 0.118
4 2.66 0.078