Protein profile

PA2591

transcriptional regulator

Genome: NC_002516.2

Gene: PA2591 Structure source: Experimental + AlphaFold UniProt Q9I0P6
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Amino acids 268
Annotations 7
Features 21
PDB binders 0
Druggability 0.245

Overview

Basic information about this protein and its source genome.

Accession
PA2591
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2591
Status
annotated
Amino acids
268
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.245
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
216 243 ProSitePatterns PS00622 LuxR-type HTH domain signature.
216 243 InterPro IPR000792 Transcription regulator LuxR, C-terminal
201 253 Pfam PF00196 Bacterial regulatory proteins, luxR family
201 253 InterPro IPR000792 Transcription regulator LuxR, C-terminal
189 257 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
189 257 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
195 260 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
195 260 InterPro IPR000792 Transcription regulator LuxR, C-terminal
32 257 PANTHER PTHR44688 -
199 256 SMART SM00421 luxrmega5
199 256 InterPro IPR000792 Transcription regulator LuxR, C-terminal
202 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
202 216 InterPro IPR000792 Transcription regulator LuxR, C-terminal
232 244 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
232 244 InterPro IPR000792 Transcription regulator LuxR, C-terminal
216 232 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
216 232 InterPro IPR000792 Transcription regulator LuxR, C-terminal
202 258 CDD cd06170 LuxR_C_like
202 258 InterPro IPR000792 Transcription regulator LuxR, C-terminal
166 259 Gene3D G3DSA:1.10.10.10 -
166 259 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5XHX
X-ray 2.10 Å A,B
72.0% 1-193
PDBe RCSB PDBj File
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AlphaFold PA2591
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.245

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.67 0.464
2 1.48 0.021