Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2605
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2605 tusD
Status: annotated
Amino acids: 131
Structure source: AlphaFold

EC

2.8.1.-

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016783 Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.373

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

2.8.1.-

Gene Ontology (GO)

7

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).
GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
GO:0016783 Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
1	127	Gene3D	G3DSA:3.40.1260.10	-
1	127	InterPro	IPR027396	DsrEFH-like
1	127	Pfam	PF02635	DsrE/DsrF-like family
1	127	InterPro	IPR003787	Sulphur relay, DsrE/F-like
1	127	SUPERFAMILY	SSF75169	DsrEFH-like
1	127	FunFam	G3DSA:3.40.1260.10:FF:000001	Sulfurtransferase TusD
1	127	PANTHER	PTHR34874	PROTEIN YCHN
2	127	NCBIfam	TIGR03012	sulfurtransferase complex subunit TusD
2	127	InterPro	IPR017463	Sulphur relay, TusD/DsrE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2605	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.373

PA2605