Protein profile

PA2606

sulfur relay protein TusC

Genome: NC_002516.2

Gene: tusC PA2606 Structure source: AlphaFold UniProt Q9I0N2

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Amino acids 119

Annotations 2

Features 10

PDB binders 0

Druggability 0.787

Overview

Basic information about this protein and its source genome.

Accession: PA2606
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tusC PA2606
Status: annotated
Amino acids: 119
Structure source: AlphaFold

GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.787

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).
GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
4	118	Pfam	PF02635	DsrE/DsrF-like family
4	118	InterPro	IPR003787	Sulphur relay, DsrE/F-like
1	119	Gene3D	G3DSA:3.40.1260.10	-
1	119	InterPro	IPR027396	DsrEFH-like
5	118	NCBIfam	TIGR03010	sulfurtransferase complex subunit TusC
5	118	InterPro	IPR017462	Sulphur relay, TusC/DsrF
3	119	PANTHER	PTHR38780	PROTEIN TUSC
3	119	InterPro	IPR017462	Sulphur relay, TusC/DsrF
4	118	SUPERFAMILY	SSF75169	DsrEFH-like
4	118	InterPro	IPR027396	DsrEFH-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2606	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.787