Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2609
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2609
Status: annotated
Amino acids: 327
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004645 Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. GO:0009032 Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. GO:0006206 The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.757

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MTLSTPAEHPFAQFVRILGKGKRGARSLTREEAREALGMILDGRVEDTQLGAFLMLLRHKEESSEELAGFTEAVRERLQVPSLRVDLDWPSYAGKKRHLPWYLLAAKCLAGHGVRILMHGGGAHTAGRLYSEQLLAALEIPLCHDWLQVEQALERGHLAFIPLGAWMPVLQRMIDLRNTLGLRSPIHSLVRLLNPLNADCILQSIFHPGYQETHREASRLLGDRAIVIKGEGGEIEVNPDVVAHLYGCDQGEAWDEEWPALSTHRHMKPEQLDPGFLRAVWDGREGDAYGHLAVLSSMALALRALGKNREEAFKEAAHYWATRNESI

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0004645 Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate.
GO:0009032 Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.
GO:0006206 The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
20	76	Pfam	PF02885	Glycosyl transferase family, helical bundle domain
20	76	InterPro	IPR017459	Glycosyl transferase family 3, N-terminal domain
81	324	SUPERFAMILY	SSF52418	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
81	324	InterPro	IPR035902	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
80	326	Gene3D	G3DSA:3.40.1030.10	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
80	326	InterPro	IPR035902	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
10	79	Gene3D	G3DSA:1.20.970.10	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
9	277	PANTHER	PTHR10515	THYMIDINE PHOSPHORYLASE
9	277	InterPro	IPR000053	Thymidine/pyrimidine-nucleoside phosphorylase
18	78	SUPERFAMILY	SSF47648	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
18	78	InterPro	IPR036320	Glycosyl transferase family 3, N-terminal domain superfamily
10	79	FunFam	G3DSA:1.20.970.10:FF:000019	Anthranilate phosphoribosyltransferase like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2609	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.757
2				0.206

PA2609