Protein profile

PA2614

outer-membrane lipoprotein carrier protein

Genome: NC_002516.2

Gene: lolA PA2614 Structure source: Experimental + AlphaFold UniProt Q9I0M4
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Amino acids 208
Annotations 4
Features 21
PDB binders 0
Druggability 0.769

Overview

Basic information about this protein and its source genome.

Accession
PA2614
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
lolA PA2614
Status
annotated
Amino acids
208
Structure source
Experimental + AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0044874 A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. GO:0042953 The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.769
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0044874 A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.
  • GO:0042953 The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
27 190 CDD cd16325 LolA
27 190 InterPro IPR004564 Outer membrane lipoprotein carrier protein LolA-like
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
24 207 FunFam G3DSA:2.50.20.10:FF:000007 Outer-membrane lipoprotein carrier protein
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
11 208 Hamap MF_00240 Outer-membrane lipoprotein carrier protein [lolA].
11 208 InterPro IPR018323 Outer membrane lipoprotein carrier protein LolA, Proteobacteria
36 198 Pfam PF03548 Outer membrane lipoprotein carrier protein LolA
36 198 InterPro IPR004564 Outer membrane lipoprotein carrier protein LolA-like
14 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
2 208 PANTHER PTHR35869 OUTER-MEMBRANE LIPOPROTEIN CARRIER PROTEIN
2 208 InterPro IPR004564 Outer membrane lipoprotein carrier protein LolA-like
7 205 NCBIfam TIGR00547 outer membrane lipoprotein chaperone LolA
7 205 InterPro IPR018323 Outer membrane lipoprotein carrier protein LolA, Proteobacteria
26 207 SUPERFAMILY SSF89392 Prokaryotic lipoproteins and lipoprotein localization factors
26 207 InterPro IPR029046 Lipoprotein localisation LolA/LolB/LppX
24 207 Gene3D G3DSA:2.50.20.10 Lipoprotein localisation LolA/LolB/LppX
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
22 208 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2W7Q
X-ray 1.88 Å A,B
89.9% 22-208
PDBe RCSB PDBj File
Viewing
AlphaFold PA2614
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.769
2 0.748
1 0.63

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.85 0.286
2 1.38 0.017
3 1.14 0.009
4 1.09 0.007
5 1.03 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

13 records

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
CHEMBL1213376 P61316 — 406.0 Da LogP 4.01 TPSA 46.1 ✓ Ro5 ✓ Clean COc1ccc(CCN2CN=C(SCc3ccc(Cl)cc3)NC2)cc1OC

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.