Protein profile

PA2615

DNA translocase FtsK

Genome: NC_002516.2

Gene: PA2615 ftsK Structure source: Experimental + AlphaFold UniProt Q9I0M3
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Amino acids 811
Annotations 8
Features 43
PDB binders 1
Druggability 0.699

Overview

Basic information about this protein and its source genome.

Accession
PA2615
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2615 ftsK
Status
annotated
Amino acids
811
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015616 Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0071236 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.699
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MRRKNSDLKDSTTASHAAAWRQQLHSRLKEGVLIALGALCLYLWMALLTYDSADPSWSHSSQVDQVQNAAGRLGAVSADILFMTLGYFAYLFPLLLGIKTWQVFRRRNLPWEWNTWLFSWRLVGLIFLILAGSALAYIHFHASGHMPASASAGGAIGQSLGRVAVDALNVQGSTLVFFALFLFGLTVFADLSWFKVMDVTGKITLDFFELIQNAFNRWMGARAERKQLVAQLREVDERVAEVVAPSVPDRREQSKAKERLLEREEALAKHMSEREKRPPPKIDPPPSPKAPEPSKRVLKEKQAPLFVDTAVEGTLPPLSLLDPAEVKQKSYSPESLEAMSRLLEIKLKEFGVEVSVDSVHPGPVITRFEIQPAAGVKVSRISNLAKDLARSLAVISVRVVEVIPGKTTVGIEIPNEDRQMVRFSEVLSSPEYDEHKSTVPLALGHDIGGRPIITDLAKMPHLLVAGTTGSGKSVGVNAMLLSILFKSTPSEARLIMIDPKMLELSIYEGIPHLLCPVVTDMKEAANALRWSVAEMERRYRLMAAMGVRNLAGFNRKVKDAEEAGTPLTDPLFRRESPDDEPPQLSTLPTIVVVVDEFADMMMIVGKKVEELIARIAQKARAAGIHLILATQRPSVDVITGLIKANIPTRIAFQVSSKIDSRTILDQGGAEQLLGHGDMLYLPPGTGLPIRVHGAFVSDDEVHRVVEAWKLRGAPDYIEDILAGVDEGGGGGGSFDGGDGSGEGSEDDPLYDEAVRFVTESRRASISAVQRKLKIGYNRAARMIEAMEMAGVVTPMNTNGSREVIAPAPVRD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015616 Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0071236 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

43 records
Show feature table
Start End DB Term Name
116 138 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 79 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
148 165 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
172 194 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
396 708 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
396 708 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
728 749 MobiDBLite mobidb-lite consensus disorder prediction
743 808 SMART SM00843 FtsK_gamma_2
743 808 InterPro IPR018541 FtsK gamma domain
425 635 Pfam PF01580 FtsK/SpoIIIE family
425 635 InterPro IPR002543 FtsK domain
73 95 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
743 806 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
743 806 InterPro IPR036390 Winged helix DNA-binding domain superfamily
246 282 MobiDBLite mobidb-lite consensus disorder prediction
175 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
745 805 Pfam PF09397 Ftsk gamma domain
745 805 InterPro IPR018541 FtsK gamma domain
21 808 PANTHER PTHR22683 SPORULATION PROTEIN RELATED
141 174 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
99 117 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
27 200 Pfam PF13491 4TM region of DNA translocase FtsK/SpoIIIE
27 200 InterPro IPR025199 DNA translocase FtsK, 4TM region
195 811 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
740 804 FunFam G3DSA:1.10.10.10:FF:000268 DNA translocase FtsK
461 654 CDD cd01127 TrwB_TraG_TraD_VirD4
420 721 FunFam G3DSA:3.40.50.300:FF:000209 Cell division protein FtsK
246 299 MobiDBLite mobidb-lite consensus disorder prediction
118 140 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
449 661 ProSiteProfiles PS50901 FtsK domain profile.
449 661 InterPro IPR002543 FtsK domain
80 98 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
739 804 Gene3D G3DSA:1.10.10.10 -
739 804 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
315 419 Gene3D G3DSA:3.30.980.40 -
315 419 FunFam G3DSA:3.30.980.40:FF:000001 DNA translocase FtsK
420 721 Gene3D G3DSA:3.40.50.300 -
420 721 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 30 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
315 415 Pfam PF17854 FtsK alpha domain
315 415 InterPro IPR041027 FtsK alpha domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2IUT
X-ray 2.25 Å A,B
69.7% 247-811
PDBe RCSB PDBj File
Viewing
PDB 2IUU
X-ray 2.90 Å A,B,C,D,E,F
59.4% 247-728
PDBe RCSB PDBj File
Loaded
PDB 2VE8
X-ray 1.40 Å A,B,C,D,E,F,G,H
9.0% 739-811
PDBe RCSB PDBj File
Loaded
PDB 2VE9
X-ray 1.90 Å A,B,C,D,E,F
9.0% 739-811
PDBe RCSB PDBj File
Loaded
AlphaFold PA2615
AlphaFold — — full sequence — Loaded
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Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

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Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
AGS
2IUT 2.25 Å Open crystal
523.2 Da LogP -1.51 TPSA 262.1 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.