Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2621
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: clpS PA2621
Status: annotated
Amino acids: 122
Structure source: AlphaFold

GO

GO:0030163 The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.928

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0030163 The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
5	33	MobiDBLite	mobidb-lite	consensus disorder prediction
19	122	Gene3D	G3DSA:3.30.1390.10	-
19	122	InterPro	IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
34	122	PANTHER	PTHR33473	ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS1, CHLOROPLASTIC
34	122	InterPro	IPR022935	ATP-dependent Clp protease adaptor protein ClpS
37	120	SUPERFAMILY	SSF54736	ClpS-like
37	120	InterPro	IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
17	116	Hamap	MF_00302	ATP-dependent Clp protease adapter protein ClpS [clpS].
17	116	InterPro	IPR022935	ATP-dependent Clp protease adaptor protein ClpS
13	28	MobiDBLite	mobidb-lite	consensus disorder prediction
39	117	Pfam	PF02617	ATP-dependent Clp protease adaptor protein ClpS
39	117	InterPro	IPR003769	Adaptor protein ClpS, core
13	121	FunFam	G3DSA:3.30.1390.10:FF:000002	ATP-dependent Clp protease adapter protein ClpS

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2621	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.928

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
Y1	1R6O	P0A8Q6	88.9 Da LogP -0.00 TPSA 0.0	✓ Ro5	✓ Clean	`[Y+2]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA2621