Protein profile

PA2622

cold-shock protein CspD

Genome: NC_002516.2

Gene: PA2622 cspD Structure source: AlphaFold UniProt Q9I0L6
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Amino acids 90
Annotations 6
Features 27
PDB binders 1
Druggability 0.969

Overview

Basic information about this protein and its source genome.

Accession
PA2622
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2622 cspD
Status
annotated
Amino acids
90
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003676 Binding to a nucleic acid. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0010468 Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.879
Human E-value
9.54e-11
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.969
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003676 Binding to a nucleic acid.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0010468 Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
3 68 PANTHER PTHR11544 COLD SHOCK DOMAIN CONTAINING PROTEINS
15 34 ProSitePatterns PS00352 Cold-shock (CSD) domain signature.
15 34 InterPro IPR019844 Cold-shock (CSD) domain
1 76 Gene3D G3DSA:2.40.50.140 -
1 76 InterPro IPR012340 Nucleic acid-binding, OB-fold
1 66 ProSiteProfiles PS51857 Cold-shock (CSD) domain profile.
1 66 InterPro IPR002059 Cold-shock protein, DNA-binding
4 64 CDD cd04458 CSP_CDS
4 64 InterPro IPR002059 Cold-shock protein, DNA-binding
1 84 PIRSF PIRSF002599 Cold_shock_A
1 84 InterPro IPR012156 Cold shock, CspA
1 65 SUPERFAMILY SSF50249 Nucleic acid-binding proteins
1 65 InterPro IPR012340 Nucleic acid-binding, OB-fold
1 67 NCBIfam TIGR02381 cold shock domain-containing protein CspD
1 67 InterPro IPR012751 CspD, cold shock
1 67 FunFam G3DSA:2.40.50.140:FF:000006 Cold shock protein CspC
3 67 SMART SM00357 csp_8
3 67 InterPro IPR011129 Cold shock domain
3 65 Pfam PF00313 'Cold-shock' DNA-binding domain
3 65 InterPro IPR002059 Cold-shock protein, DNA-binding
66 90 MobiDBLite mobidb-lite consensus disorder prediction
25 34 PRINTS PR00050 Cold shock protein signature
25 34 InterPro IPR002059 Cold-shock protein, DNA-binding
4 19 PRINTS PR00050 Cold shock protein signature
4 19 InterPro IPR002059 Cold-shock protein, DNA-binding
40 58 PRINTS PR00050 Cold shock protein signature
40 58 InterPro IPR002059 Cold-shock protein, DNA-binding

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2622
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.969
1 0.425
2 0.257

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

24 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NHE
6T00
P32081 207.3 Da LogP 0.80 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCS(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.