Protein profile

PA2627

high frequency lysogenization protein HflD

Genome: NC_002516.2

Gene: PA2627 hflD Structure source: AlphaFold UniProt Q9I0L1

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Amino acids 206

Annotations 2

Features 11

PDB binders 0

Druggability 0.438

Overview

Basic information about this protein and its source genome.

Accession: PA2627
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2627 hflD
Status: annotated
Amino acids: 206
Structure source: AlphaFold

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.438

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
3	205	SUPERFAMILY	SSF101322	YcfC-like
3	205	InterPro	IPR035932	HflD-like superfamily
2	205	PANTHER	PTHR38100	HIGH FREQUENCY LYSOGENIZATION PROTEIN HFLD
2	205	InterPro	IPR007451	High frequency lysogenization protein HflD
7	197	Pfam	PF04356	Protein of unknown function (DUF489)
7	197	InterPro	IPR007451	High frequency lysogenization protein HflD
2	205	Gene3D	G3DSA:1.10.3890.10	-
2	205	InterPro	IPR035932	HflD-like superfamily
1	205	Hamap	MF_00695	High frequency lysogenization protein HflD [hflD].
1	205	InterPro	IPR007451	High frequency lysogenization protein HflD
2	205	FunFam	G3DSA:1.10.3890.10:FF:000003	High frequency lysogenization protein HflD homolog

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2627	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.438
2				0.429
4				0.415