Protein profile

PA2628

hypothetical protein

Genome: NC_002516.2

Gene: PA2628 Structure source: AlphaFold UniProt Q9I0L0
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Amino acids 296
Annotations 1
Features 40
PDB binders 0
Druggability 0.911

Overview

Basic information about this protein and its source genome.

Accession
PA2628
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2628
Status
annotated
Amino acids
296
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
25.413
Human E-value
3.54e-15
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.911
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
69 79 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
131 147 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 17 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 150 Gene3D G3DSA:1.10.3730.20 -
289 296 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
125 130 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
16 281 PANTHER PTHR22911 ACYL-MALONYL CONDENSING ENZYME-RELATED
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
264 268 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
243 263 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
153 175 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 105 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
176 186 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
208 212 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
187 207 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
232 242 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
270 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
213 231 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 38 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
17 147 Pfam PF00892 EamA-like transporter family
17 147 InterPro IPR000620 EamA domain
158 283 Pfam PF00892 EamA-like transporter family
158 283 InterPro IPR000620 EamA domain
18 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
190 290 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
106 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
153 175 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
48 68 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
80 100 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
269 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
148 152 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 38 Phobius SIGNAL_PEPTIDE Signal peptide region
102 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
214 231 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
238 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
131 148 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
187 209 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
50 151 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
15 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2628
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.911