Overview
Basic information about this protein and its source genome.
- Accession
- PA2630
- Gene
- PA2630
- Status
- annotated
- Amino acids
- 389
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
MNADTPLQLLGGLTAAEFLRDYWQRKPLLVRQAIPDFESPLSADELAGLSLEESVESRIVLEHGKTPWEMRRGPFQEEDYQHLPEQDWTLLVQAVDQFVPEVAQLLEQFRFLPSWRIDDVMISYAAPGGGVGPHFDNYDVFLLQGHGRRRWKVGQMCSSDSPLREHADLRILADFEQSDEWVLEPGDMLYLPPRLAHYGIAEDECMTYSIGFRAPSAAEVLTHFTDFLGQFLSDEERYTDAGLQPVGDDPHQIQRDALERLQGLIQEHMSDERLLLTWFGQFMTEPRYPELVAGEEIPEEELFGALEDGALLVRNPSARLAWSEIDIGLVLFASGQSVLLPGQLKELLKLVCSADALHLENLGQWLADDDARKLLAELVKQGSLEFADE
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
2- GO:0016706 Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
- GO:0046872 Binding to a metal ion.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 214 | Gene3D | G3DSA:2.60.120.650 | Cupin |
| 104 | 219 | Pfam | PF08007 | JmjC domain |
| 104 | 219 | InterPro | IPR003347 | JmjC domain |
| 101 | 229 | ProSiteProfiles | PS51184 | JmjC domain profile. |
| 101 | 229 | InterPro | IPR003347 | JmjC domain |
| 215 | 389 | Gene3D | G3DSA:3.40.366.30 | 50S ribosomal protein L16 arginine hydroxylase; Chain A, Domain 2 |
| 5 | 226 | PANTHER | PTHR13096 | MINA53 MYC INDUCED NUCLEAR ANTIGEN |
| 5 | 226 | InterPro | IPR039994 | JmjC domain-containing |
| 267 | 385 | Pfam | PF20514 | ROXA-like winged helix |
| 267 | 385 | InterPro | IPR046799 | ROXA-like, winged helix |
| 101 | 225 | SMART | SM00558 | cupin_9 |
| 101 | 225 | InterPro | IPR003347 | JmjC domain |
| 6 | 300 | SUPERFAMILY | SSF51197 | Clavaminate synthase-like |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA2630
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.735 | ||||||
| 4 | 0.632 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| AKG | P27431 | 146.1 Da LogP -0.50 TPSA 91.7 | ✓ Ro5 | ✓ Clean |
C(CC(=O)O)C(=O)C(=O)O
|
|
| OGA | D0MK34 | 147.1 Da LogP -1.73 TPSA 103.7 | ✓ Ro5 | ✓ Clean |
C(C(=O)O)NC(=O)C(=O)O
|
|
| SIN | P27431 | 118.1 Da LogP -0.06 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
C(CC(=O)O)C(=O)O
|
|
| UN9 | D0MK34 | 280.7 Da LogP 1.41 TPSA 99.5 | ✓ Ro5 | ✓ Clean |
c1ccc2c(c1)c(c(nc2Cl)C(=O)NCC(=O)O)O
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC7670 | 1.000 | 280.7 Da LogP 1.41 TPSA 99.5 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1nc(Cl)c2ccccc2c1O
|
| ZINC35570360 | 0.667 | 223.6 Da LogP 2.29 TPSA 70.4 | ✓ Ro5 | ✓ Clean |
O=C(O)c1nc(Cl)c2ccccc2c1O
|
| ZINC3593496 | 0.652 | 206.2 Da LogP -1.16 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
COC(=O)C[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC3593497 | 0.652 | 206.2 Da LogP -1.16 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
COC(=O)C[C@](O)(CC(=O)O)C(=O)O
|
| ZINC14686440 | 0.625 | 436.4 Da LogP -2.64 TPSA 247.9 | 1 viol. | ✓ Clean |
O=C(O)C[C@](O)(CC(=O)NCCCCNC(=O)C[C@@](O)(CC(=O…
|
| ZINC14686442 | 0.625 | 436.4 Da LogP -2.64 TPSA 247.9 | 1 viol. | ✓ Clean |
O=C(O)C[C@@](O)(CC(=O)NCCCCNC(=O)C[C@](O)(CC(=O…
|
| ZINC14686444 | 0.625 | 436.4 Da LogP -2.64 TPSA 247.9 | 1 viol. | ✓ Clean |
O=C(O)C[C@@](O)(CC(=O)NCCCCNC(=O)C[C@@](O)(CC(=…
|
| ZINC1529497 | 0.615 | 230.3 Da LogP 3.06 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCC(=O)O
|
| ZINC1531045 | 0.615 | 202.2 Da LogP 2.28 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCC(=O)O
|
| ZINC1593115 | 0.615 | 216.3 Da LogP 2.67 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCC(=O)O
|
| ZINC1700020 | 0.615 | 244.3 Da LogP 3.45 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCC(=O)O
|
| ZINC3860440 | 0.615 | 258.4 Da LogP 3.84 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCCC(=O)O
|
| ZINC3861298 | 0.615 | 286.4 Da LogP 4.62 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCCCCC(=O)O
|
| ZINC5113062 | 0.615 | 272.4 Da LogP 4.23 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCCCC(=O)O
|
| ZINC38342145 | 0.600 | 237.6 Da LogP 2.38 TPSA 59.4 | ✓ Ro5 | ✓ Clean |
COC(=O)c1nc(Cl)c2ccccc2c1O
|
| ZINC13398039 | 0.577 | 234.2 Da LogP -0.38 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
CC(C)OC(=O)C[C@](O)(CC(=O)O)C(=O)O
|
| ZINC2528012 | 0.577 | 234.2 Da LogP -0.38 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
CC(C)OC(=O)C[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC1572706 | 0.563 | 260.2 Da LogP -1.05 TPSA 132.8 | ✓ Ro5 | ✓ Clean |
O=C(O)CCC(=O)NCCNC(=O)CCC(=O)O
|
| ZINC146315135 | 0.560 | 204.2 Da LogP 0.86 TPSA 94.8 | ✓ Ro5 | ✓ Clean |
CCCCC[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC146315336 | 0.560 | 204.2 Da LogP 0.86 TPSA 94.8 | ✓ Ro5 | ✓ Clean |
CCCCC[C@](O)(CC(=O)O)C(=O)O
|
| ZINC71257465 | 0.540 | 352.3 Da LogP 2.86 TPSA 108.8 | ✓ Ro5 | ✓ Clean |
Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12
|
| ZINC1703342 | 0.533 | 202.2 Da LogP 1.07 TPSA 91.7 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCC(=O)CCCC(=O)O
|
| ZINC1728397 | 0.533 | 233.2 Da LogP -0.29 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CCN(CCC(=O)O)CCC(=O)O
|
| ZINC2508031 | 0.533 | 230.3 Da LogP 1.85 TPSA 91.7 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCC(=O)CCCCC(=O)O
|
| ZINC2517013 | 0.533 | 250.2 Da LogP 0.89 TPSA 111.9 | ✓ Ro5 | ✓ Clean |
O=C(O)CCP(CCC(=O)O)CCC(=O)O
|
| ZINC1697439 | 0.529 | 219.5 Da LogP 1.79 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
O=C(O)CCC(=O)C(Cl)(Cl)Cl
|
| ZINC35465466 | 0.529 | 244.3 Da LogP 2.24 TPSA 91.7 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCC(=O)CCC(=O)O
|
| ZINC39208104 | 0.529 | 262.2 Da LogP -0.20 TPSA 127.2 | ✓ Ro5 | ✓ Clean |
O=C(O)CCC(=O)OCCOC(=O)CCC(=O)O
|
| ZINC2454766 | 0.525 | 229.2 Da LogP 1.65 TPSA 66.4 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1cccc2ccccc12
|
| ZINC11920158 | 0.524 | 219.2 Da LogP 0.38 TPSA 95.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1n[nH]c2ccccc12
|
| ZINC13398014 | 0.522 | 220.2 Da LogP -1.07 TPSA 110.1 | ✓ Ro5 | ✓ Clean |
COC(=O)CC(O)(CC(=O)OC)C(=O)O
|
| ZINC3861629 | 0.522 | 206.1 Da LogP -1.16 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
COC(=O)C(O)(CC(=O)O)CC(=O)O
|
| ZINC39799 | 0.513 | 213.6 Da LogP 1.15 TPSA 66.4 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1ccccc1Cl
|
| ZINC100969993 | 0.500 | 359.5 Da LogP 2.70 TPSA 123.9 | ✓ Ro5 | ✓ Clean |
CCCCCCCCCCCCNC(=O)C[C@](O)(CC(=O)O)C(=O)O
|
| ZINC100969996 | 0.500 | 359.5 Da LogP 2.70 TPSA 123.9 | ✓ Ro5 | ✓ Clean |
CCCCCCCCCCCCNC(=O)C[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC1753095 | 0.500 | 238.3 Da LogP 1.40 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCSCCSCCC(=O)O
|
| ZINC3175470 | 0.500 | 458.4 Da LogP 2.08 TPSA 158.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1cc(-c2cc(C(=O)NCC(=O)O)c3ccccc3n…
|
| ZINC38682833 | 0.500 | 286.3 Da LogP -0.61 TPSA 115.2 | ✓ Ro5 | ✓ Clean |
O=C(O)CCC(=O)N1CCN(C(=O)CCC(=O)O)CC1
|
| ZINC4181831 | 0.500 | 232.2 Da LogP -0.01 TPSA 129.0 | ✓ Ro5 | ✓ Clean |
O=C(O)CCC(=O)C(CC(=O)O)CC(=O)O
|
| ZINC6432 | 0.500 | 246.2 Da LogP 0.75 TPSA 99.5 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1nc2ccccc2cc1O
|
| ZINC72400984 | 0.500 | 340.8 Da LogP 3.37 TPSA 79.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CNC(=O)c1cc(-c2ccccc2Cl)nc2ccccc12
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.