Protein profile

PA2634

isocitrate lyase

Genome: NC_002516.2

Gene: aceA Structure source: ColabFold
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Amino acids 531
Annotations 3
Features 20
PDB binders 9
Druggability 0.875

Overview

Basic information about this protein and its source genome.

Accession
PA2634
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
aceA
Status
annotated
Amino acids
531
Structure source
ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019752 The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0004451 Catalysis of the reaction: isocitrate = glyoxylate + succinate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.875
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0019752 The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
  • GO:0004451 Catalysis of the reaction: isocitrate = glyoxylate + succinate.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
10 514 SUPERFAMILY SSF51621 Phosphoenolpyruvate/pyruvate domain
10 514 InterPro IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
1 277 PIRSF PIRSF001362 ICL
1 277 InterPro IPR006254 Isocitrate lyase
294 410 PIRSF PIRSF001362 ICL
294 410 InterPro IPR006254 Isocitrate lyase
412 531 PIRSF PIRSF001362 ICL
412 531 InterPro IPR006254 Isocitrate lyase
2 531 Gene3D G3DSA:3.20.20.60 -
2 531 InterPro IPR040442 Pyruvate kinase-like domain superfamily
81 269 Pfam PF00463 Isocitrate lyase family
81 269 InterPro IPR006254 Isocitrate lyase
429 530 Pfam PF00463 Isocitrate lyase family
429 530 InterPro IPR006254 Isocitrate lyase
330 399 Pfam PF00463 Isocitrate lyase family
330 399 InterPro IPR006254 Isocitrate lyase
63 386 CDD cd00377 ICL_PEPM
63 386 InterPro IPR039556 ICL/PEPM domain
2 531 PANTHER PTHR21631 ISOCITRATE LYASE/MALATE SYNTHASE
2 531 InterPro IPR006254 Isocitrate lyase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA2634
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.875

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

66 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3NP
6C4A
P9WKK7 119.1 Da LogP -0.26 TPSA 80.4 ✓ Ro5 ✓ Clean C(C[N+](=O)[O-])C(=O)O
GLV
6G1O
Q9I0K4 74.0 Da LogP -0.73 TPSA 54.4 ✓ Ro5 ✓ Clean C(=O)C(=O)O
ICT
3P0X
Q2YQA0 192.1 Da LogP -1.39 TPSA 132.1 ✓ Ro5 ✓ Clean C([C@@H]([C@H](C(=O)O)O)C(=O)O)C(=O)O
MLA
3OQ8
Q2YQA0 104.1 Da LogP -0.45 TPSA 74.6 ✓ Ro5 ✓ Clean C(C(=O)O)C(=O)O
OXD
6VB9
P9WKK7 90.0 Da LogP -0.84 TPSA 74.6 ✓ Ro5 ✓ Clean C(=O)(C(=O)O)O
PYR
1F8M
P9WKK7 88.1 Da LogP -0.34 TPSA 54.4 ✓ Ro5 ✓ Clean CC(=O)C(=O)O
SIN
1F8I
P9WKK7 118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O
U9S
6WSI
P9WKK7 132.1 Da LogP -1.08 TPSA 87.1 ✓ Ro5 ✓ Clean [C@@H]1([C@H](O1)C(=O)O)C(=O)O
VGX
5DQL
P9WKK7 118.1 Da LogP -0.98 TPSA 74.6 ✓ Ro5 ✓ Clean C(CO)C(=O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.