Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2652
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: ctpM PA2652
Status: annotated
Amino acids: 561
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0050918 The directed movement of a motile cell or organism towards a higher concentration of a chemical. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 21.254
Human E-value: 6.16e-07
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.942

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0050918 The directed movement of a motile cell or organism towards a higher concentration of a chemical.
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

45 records

Show feature table

Start	End	DB	Term	Name
333	356	MobiDBLite	mobidb-lite	consensus disorder prediction
1	39	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
30	206	Gene3D	G3DSA:3.30.450.20	PAS domain
10	21	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
10	32	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
230	284	ProSiteProfiles	PS50885	HAMP domain profile.
230	284	InterPro	IPR003660	HAMP domain
45	136	SMART	SM01049	Cache_2_2
45	136	InterPro	IPR033480	Single Cache domain 2
233	279	CDD	cd06225	HAMP
22	26	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
230	561	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
293	317	Coils	Coil	Coil
344	526	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
344	526	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
289	525	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
289	525	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
299	560	SMART	SM00283	MA_2
299	560	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
27	205	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15	560	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
230	284	SMART	SM00304	HAMP_11
326	525	CDD	cd11386	MCP_signal
426	455	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
426	455	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
397	424	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
397	424	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
6	31	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
6	31	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
320	349	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
320	349	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
234	561	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	26	Phobius	SIGNAL_PEPTIDE	Signal peptide region
206	233	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
228	280	Pfam	PF00672	HAMP domain
228	280	InterPro	IPR003660	HAMP domain
252	561	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
51	196	Pfam	PF17200	Single Cache domain 2
51	196	InterPro	IPR033480	Single Cache domain 2
206	228	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
476	538	ProSiteProfiles	PS50192	t-SNARE coiled-coil homology domain profile.
476	538	InterPro	IPR000727	Target SNARE coiled-coil homology domain
230	561	Gene3D	G3DSA:1.10.287.950	-
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
489	509	Coils	Coil	Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2652	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
7				0.82
2				0.656
4				0.338
3				0.261

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

4 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ACM	3UB7	B6JPK4	59.1 Da LogP -0.51 TPSA 43.1	✓ Ro5	✓ Clean	`CC(=O)N`
ARF	3UB8	B6JPK4	45.0 Da LogP -0.90 TPSA 43.1	✓ Ro5	✓ Clean	`C(=O)N`
NHY	3UB9	B6JPK4	76.1 Da LogP -0.96 TPSA 75.4	✓ Ro5	✓ Clean	`C(=O)(N)NO`
PYR	4EXO	Q87T87	88.1 Da LogP -0.34 TPSA 54.4	✓ Ro5	✓ Clean	`CC(=O)C(=O)O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA2652