Protein profile

PA2653

transporter

Genome: NC_002516.2

Gene: PA2653 Structure source: AlphaFold UniProt Q9I0I5
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Amino acids 441
Annotations 2
Features 48
PDB binders 0
Druggability 0.917

Overview

Basic information about this protein and its source genome.

Accession
PA2653
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2653
Status
annotated
Amino acids
441
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.917
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

48 records
Show feature table
Start End DB Term Name
25 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 441 PANTHER PTHR37821 AMINO ACID TRANSPORTER YUIF-RELATED
282 292 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
389 422 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
363 388 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
81 99 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
117 121 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
236 256 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
314 332 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
98 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
352 362 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
58 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
151 435 Pfam PF03553 Na+/H+ antiporter family
151 435 InterPro IPR018461 Na+/H+ antiporter, NhaC-like, C-terminal
216 235 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
333 351 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
173 191 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
418 440 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
257 261 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
119 138 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
325 347 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
293 310 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
192 214 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 88 Pfam PF13726 Na+-H+ antiporter family
2 88 InterPro IPR032813 Putative Na+/H+ antiporter, N-terminal
192 215 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
360 382 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 40 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
139 146 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
150 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
262 281 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
293 313 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
100 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
441 441 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
261 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
423 440 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 138 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 35 PRINTS PR00173 Glutamate-aspartate symporter signature
374 393 PRINTS PR00173 Glutamate-aspartate symporter signature
182 204 PRINTS PR00173 Glutamate-aspartate symporter signature
253 272 PRINTS PR00173 Glutamate-aspartate symporter signature
3 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
235 257 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2653
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.518
6 0.508
1 0.236