Protein profile

PA2675

type II secretion system protein

Genome: NC_002516.2

Gene: PA2675 Structure source: AlphaFold UniProt Q9I0G3
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Amino acids 144
Annotations 3
Features 22
PDB binders 1
Druggability 0.856

Overview

Basic information about this protein and its source genome.

Accession
PA2675
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2675
Status
annotated
Amino acids
144
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.856
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 33 PRINTS PR00813 Bacterial general secretion pathway protein G signature
8 33 InterPro IPR000983 Bacterial general secretion pathway protein G-type pilin
44 62 PRINTS PR00813 Bacterial general secretion pathway protein G signature
44 62 InterPro IPR000983 Bacterial general secretion pathway protein G-type pilin
117 144 MobiDBLite mobidb-lite consensus disorder prediction
7 27 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site.
7 27 InterPro IPR012902 Prokaryotic N-terminal methylation site
7 141 NCBIfam TIGR01710 type II secretion system major pseudopilin GspG
7 141 InterPro IPR010054 Type II secretion system protein GspG
34 140 SUPERFAMILY SSF54523 Pili subunits
34 140 InterPro IPR045584 Pilin-like
4 28 Pfam PF07963 Prokaryotic N-terminal methylation motif
4 28 InterPro IPR012902 Prokaryotic N-terminal methylation site
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
34 144 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
22 139 Gene3D G3DSA:3.30.700.10 Glycoprotein, Type 4 Pilin
31 139 Pfam PF08334 Type II secretion system (T2SS), protein G
31 139 InterPro IPR013545 Type II secretion system protein GspG, C-terminal
6 28 NCBIfam TIGR02532 prepilin-type N-terminal cleavage/methylation domain
6 28 InterPro IPR012902 Prokaryotic N-terminal methylation site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2675
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.856

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

16 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NHE
3G20
Q7BSV8 207.3 Da LogP 0.80 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCS(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.