Protein profile

PA2676

type II secretion system protein

Genome: NC_002516.2

Gene: PA2676 Structure source: AlphaFold UniProt Q9I0G2
Export view
Amino acids 395
Annotations 2
Features 30
PDB binders 1
Druggability 0.863

Overview

Basic information about this protein and its source genome.

Accession
PA2676
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2676
Status
annotated
Amino acids
395
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.863
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
185 214 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
215 233 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 161 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
367 387 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
216 238 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
162 184 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
47 164 Gene3D G3DSA:1.20.81.30 Type II secretion system (T2SS), domain F
47 164 InterPro IPR042094 Type II secretion system GspF domain superfamily
395 395 Coils Coil Coil
388 395 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58 70 PRINTS PR00812 Bacterial general secretion pathway protein F signature
58 70 InterPro IPR003004 GspF/PilC family
157 185 PRINTS PR00812 Bacterial general secretion pathway protein F signature
157 185 InterPro IPR003004 GspF/PilC family
359 373 PRINTS PR00812 Bacterial general secretion pathway protein F signature
359 373 InterPro IPR003004 GspF/PilC family
375 394 PRINTS PR00812 Bacterial general secretion pathway protein F signature
375 394 InterPro IPR003004 GspF/PilC family
1 394 PANTHER PTHR30012 GENERAL SECRETION PATHWAY PROTEIN
1 394 InterPro IPR003004 GspF/PilC family
248 363 FunFam G3DSA:1.20.81.30:FF:000001 Type II secretion system protein F
234 366 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
162 184 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
247 360 Gene3D G3DSA:1.20.81.30 Type II secretion system (T2SS), domain F
247 360 InterPro IPR042094 Type II secretion system GspF domain superfamily
366 388 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 185 Pfam PF00482 Type II secretion system (T2SS), protein F
63 185 InterPro IPR018076 Type II secretion system protein GspF domain
265 385 Pfam PF00482 Type II secretion system (T2SS), protein F
265 385 InterPro IPR018076 Type II secretion system protein GspF domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2676
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.863
5 0.577
15 0.509
1 0.492

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
PE5
3C1Q
P45780 398.5 Da LogP 0.13 TPSA 94.1 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.