Amino acids
1317
Annotations
2
Features
43
PDB binders
0
Druggability
0.752
Overview
Basic information about this protein and its source genome.
- Accession
- PA2684
- Gene
- tse5 PA2684
- Status
- annotated
- Amino acids
- 1317
- Structure source
- AlphaFold
GO
GO:0097351 Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- OuterMembrane
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.752
Sequence
Primary amino-acid sequence viewer.
MSGLPVSHVGEKVSGGVISTGSPTVHVGSSAVGLADRVSACVPLVGKPVNPMLGSKLLPEEVDFALAAPDTFTFARGYLSSNPRIGRLGRGWWLPGESMHLELSEDACVLVDAQGRRIGFPALAPGAQHYSGSEELWLRRGGSSGGEAQAWRGRWAAVPAELQTQEGSVLVLSGHSYLHFQRCPDGIWRLQASFGRAGYRTEFRWSGRGLLTGVRDSAGRSYALVYQQACEPSEGDDGLRLFGVILASHDGPPPDYIDPQSPGLDWLVRYQFSDSGDLIAVRDRLGQVVRVFAWREHMLVAHGEPGGLEVRYEWDVHAPHGRVVKQIEAGGLTRTFRYLRDATEVSDSLGRVERYEFAGEGGQRRWTALVRADGSRSEFDYDLFGRLVAMRDPLGRETRRRRDGQGRMLEEESPGKARYRKRVDEETGLLVELEDAMQRRWTFERDERGNATTVRGPAGSTRYAYEDPRLPDRPTRIVDPRGGERRLEWNRFGLLAALTDCSGQVWRYDYDNEGRLVASSDPLGQLTRRRYDPLGQLIGLELADGSALSYEYDALGRQTRIADAEGHATLFSWGHGDLLARVSDAGGGELSYLHDEAGRLVALTNENGVQAQFRYDLLDRLVEETGFDGRRQRYRYNAADELIAREDADGRETTYAYDRDGRLASIRVPATEHAPALVERYRWLADGRLASAGGADCEVRYTYDEVGNLRLESQVHADGWVYSVEHSHDALGVRQTSRYGDAPPVAWLTYGPGHLHGALVGAVELAFERDALHREVRRDARRDGQDDALFTQERQHAPLGRLQRSRLRLAGGFDWQRGYRYDGLGQLVGIDDNQYPSVRYEYDLGGRLLASRRAGAAASTYRYDAAGNRLEGVGEHAREDARQAFAENELYRSGFSRSETRASQAGEGPARWAGNRVERIAGNRYRFDALGNLVERIGADGERLRLAYDGAQRLVHLTRDYADGTRLEARYRYDALSRRIAKVVLRDGVEQQVRFGWDGDRQCAEAFARELRTTVHEPGGFVPLLRLEQACEPDPPELLQLRQAFAAEGQPLPAQCVPALGEARIAFFHTDHLGTPLQLSDERGQLRWQGVPDDWRAVAPERQPGAQPIRFQGQYHDEESGLYYNRYRYYLPEAGRYASQDPLGLGGGPNPYAYALNAPTLAYDPTGLIIPLVVIGAFAARAAIGAALGAGIELGMQTGKQVLGQMKDNWDSDRDLTDIKWKCIDINWKHVGASAAIGTVAPGMLSTGKTVVQSAKAIRTLSGQAANTANRAAKLAARKAAHADTIKKAVATQAAWQTGKQIVKCPLKDEEEECPPQ
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
2 GO
Gene Ontology (GO)
2- GO:0097351 Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
- GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
Sequence Features
Domain/signature hits from InterPro and related databases.
43 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1105 | 1168 | NCBIfam | TIGR03696 | RHS repeat-associated core domain |
| 1105 | 1168 | InterPro | IPR022385 | Rhs repeat-associated core |
| 927 | 965 | Pfam | PF05593 | RHS Repeat |
| 927 | 965 | InterPro | IPR031325 | RHS repeat |
| 595 | 630 | Pfam | PF05593 | RHS Repeat |
| 595 | 630 | InterPro | IPR031325 | RHS repeat |
| 636 | 670 | Pfam | PF05593 | RHS Repeat |
| 636 | 670 | InterPro | IPR031325 | RHS repeat |
| 489 | 524 | Pfam | PF05593 | RHS Repeat |
| 489 | 524 | InterPro | IPR031325 | RHS repeat |
| 531 | 566 | Pfam | PF05593 | RHS Repeat |
| 531 | 566 | InterPro | IPR031325 | RHS repeat |
| 22 | 1301 | PANTHER | PTHR32305 | - |
| 629 | 1167 | Gene3D | G3DSA:2.180.10.10 | - |
| 1 | 1167 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 395 | 415 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 636 | 669 | NCBIfam | TIGR01643 | YD repeat (two copies) |
| 636 | 669 | InterPro | IPR006530 | YD repeat |
| 531 | 570 | NCBIfam | TIGR01643 | YD repeat (two copies) |
| 531 | 570 | InterPro | IPR006530 | YD repeat |
| 367 | 399 | NCBIfam | TIGR01643 | YD repeat (two copies) |
| 367 | 399 | InterPro | IPR006530 | YD repeat |
| 381 | 415 | NCBIfam | TIGR01643 | YD repeat (two copies) |
| 381 | 415 | InterPro | IPR006530 | YD repeat |
| 594 | 634 | NCBIfam | TIGR01643 | YD repeat (two copies) |
| 594 | 634 | InterPro | IPR006530 | YD repeat |
| 489 | 528 | NCBIfam | TIGR01643 | YD repeat (two copies) |
| 489 | 528 | InterPro | IPR006530 | YD repeat |
| 1168 | 1192 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 416 | 436 | Coils | Coil | Coil |
| 496 | 701 | SUPERFAMILY | SSF69304 | Tricorn protease N-terminal domain |
| 46 | 120 | Pfam | PF20148 | Domain of unknown function (DUF6531) |
| 46 | 120 | InterPro | IPR045351 | Domain of unknown function DUF6531 |
| 1193 | 1317 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 181 | 628 | Gene3D | G3DSA:2.180.10.10 | - |
| 1112 | 1132 | PRINTS | PR00394 | RHS protein signature |
| 1112 | 1132 | InterPro | IPR001826 | RHS protein |
| 1059 | 1079 | PRINTS | PR00394 | RHS protein signature |
| 1059 | 1079 | InterPro | IPR001826 | RHS protein |
| 1135 | 1154 | PRINTS | PR00394 | RHS protein signature |
| 1135 | 1154 | InterPro | IPR001826 | RHS protein |
| 1065 | 1102 | Pfam | PF03527 | RHS protein |
| 1065 | 1102 | InterPro | IPR001826 | RHS protein |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA2684
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.752 |