Protein profile

PA2719

hypothetical protein

Genome: NC_002516.2

Gene: PA2719 Structure source: AlphaFold UniProt Q9I0C3
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Amino acids 228
Annotations 3
Features 8
PDB binders 0
Druggability 0.605

Overview

Basic information about this protein and its source genome.

Accession
PA2719
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2719
Status
annotated
Amino acids
228
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0019172 Catalysis of the reaction: methylglyoxal + H2O = D-lactate. GO:0019243 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.757
Human E-value
2.31e-09
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.605
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0019172 Catalysis of the reaction: methylglyoxal + H2O = D-lactate.
  • GO:0019243 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
2 227 Gene3D G3DSA:3.40.50.880 -
2 227 InterPro IPR029062 Class I glutamine amidotransferase-like
3 226 PANTHER PTHR48094 PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED
1 227 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
1 227 InterPro IPR029062 Class I glutamine amidotransferase-like
5 227 CDD cd03141 GATase1_Hsp31_like
28 223 Pfam PF01965 DJ-1/PfpI family
28 223 InterPro IPR002818 DJ-1/PfpI

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2719
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.605