Protein profile

PA2732

hypothetical protein

Genome: NC_002516.2

Gene: PA2732 Structure source: AlphaFold UniProt Q9I0B0
Export view
Amino acids 1146
Annotations 6
Features 19
PDB binders 0
Druggability 0.537

Overview

Basic information about this protein and its source genome.

Accession
PA2732
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2732
Status
annotated
Amino acids
1146
Structure source
AlphaFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0009035 Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. GO:0009307 A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0006304 The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.537
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0009035 Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
  • GO:0009307 A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme.
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0006304 The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
48 932 PANTHER PTHR42927 HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN
117 280 Gene3D G3DSA:3.90.1570.50 -
136 226 Pfam PF04313 Type I restriction enzyme R protein N terminus (HSDR_N)
136 226 InterPro IPR007409 Restriction endonuclease, type I, HsdR, N-terminal
297 508 Gene3D G3DSA:3.40.50.300 -
297 508 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
318 748 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
318 748 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
954 974 Coils Coil Coil
646 749 Gene3D G3DSA:3.40.50.300 -
646 749 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
312 513 ProSiteProfiles PS51192 Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile.
312 513 InterPro IPR014001 Helicase superfamily 1/2, ATP-binding domain
293 524 SMART SM00487 ultradead3
293 524 InterPro IPR014001 Helicase superfamily 1/2, ATP-binding domain
300 541 Pfam PF18766 SWI2/SNF2 ATPase
300 541 InterPro IPR040980 SWI2/SNF2 ATPase
258 504 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
258 504 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2732
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.346
42 0.284