Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2735
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2735
Status: annotated
Amino acids: 792
Structure source: AlphaFold

EC

2.1.1.72

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008170 Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. GO:0009007 Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. GO:0009307 A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.422

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

2.1.1.72

Gene Ontology (GO)

8

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0008170 Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
GO:0009007 Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.
GO:0009307 A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme.
GO:0032259 The process in which a methyl group is covalently attached to a molecule.
GO:0003676 Binding to a nucleic acid.
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0006306 OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
1	412	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
230	244	PRINTS	PR00507	N12 class N6 adenine-specific DNA methyltransferase signature
311	323	PRINTS	PR00507	N12 class N6 adenine-specific DNA methyltransferase signature
199	215	PRINTS	PR00507	N12 class N6 adenine-specific DNA methyltransferase signature
176	492	Pfam	PF02384	N-6 DNA Methylase
176	492	InterPro	IPR003356	DNA methylase, adenine-specific
413	438	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
178	507	Gene3D	G3DSA:3.40.50.150	Vaccinia Virus protein VP39
178	507	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
439	792	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
16	150	Pfam	PF12161	HsdM N-terminal domain
16	150	InterPro	IPR022749	N6 adenine-specific DNA methyltransferase, N-terminal domain
314	320	ProSitePatterns	PS00092	N-6 Adenine-specific DNA methylases signature.
314	320	InterPro	IPR002052	DNA methylase, N-6 adenine-specific, conserved site
15	569	SUPERFAMILY	SSF53335	S-adenosyl-L-methionine-dependent methyltransferases
15	569	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
9	676	PANTHER	PTHR42933	SLR6095 PROTEIN
569	592	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2735	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.332
4				0.285
3				0.244

PA2735