Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2737
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: NP_251427.2
Status: annotated
Amino acids: 118
Structure source: ColabFold

GO

GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.591

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
19	93	CDD	cd04765	HTH_MlrA-like_sg2
18	88	ProSiteProfiles	PS50937	MerR-type HTH domain profile.
18	88	InterPro	IPR000551	MerR-type HTH domain
16	117	PANTHER	PTHR30204	REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR
16	117	InterPro	IPR047057	MerR transcriptional regulator
19	87	Pfam	PF13411	MerR HTH family regulatory protein
19	87	InterPro	IPR000551	MerR-type HTH domain
14	118	FunFam	G3DSA:1.10.1660.10:FF:000003	MerR family transcriptional regulator
17	113	SUPERFAMILY	SSF46955	Putative DNA-binding domain
17	113	InterPro	IPR009061	Putative DNA-binding domain superfamily
14	118	Gene3D	G3DSA:1.10.1660.10	-
19	89	SMART	SM00422	merrmega3
19	89	InterPro	IPR000551	MerR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold PA2737	ColabFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.591
1				0.216

PA2737