Protein profile

PA2743

translation initiation factor IF-3

Genome: NC_002516.2

Gene: infC PA2743 Structure source: AlphaFold UniProt Q9I0A0
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Amino acids 183
Annotations 5
Features 21
PDB binders 3
Druggability 0.449

Overview

Basic information about this protein and its source genome.

Accession
PA2743
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
infC PA2743
Status
annotated
Amino acids
183
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043022 Binding to a ribosome. GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0032790 The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. GO:0006413 The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.449
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0043022 Binding to a ribosome.
  • GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
  • GO:0032790 The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
  • GO:0006413 The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
9 182 Hamap MF_00080 Translation initiation factor IF-3 [infC].
9 182 InterPro IPR001288 Translation initiation factor 3
19 85 Pfam PF05198 Translation initiation factor IF-3, N-terminal domain
19 85 InterPro IPR019814 Translation initiation factor 3, N-terminal
17 90 SUPERFAMILY SSF54364 Translation initiation factor IF3, N-terminal domain
17 90 InterPro IPR036787 Translation initiation factor 3 (IF-3), N-terminal domain superfamily
13 87 FunFam G3DSA:3.10.20.80:FF:000001 Translation initiation factor IF-3
43 63 Coils Coil Coil
88 183 Gene3D G3DSA:3.30.110.10 -
88 183 InterPro IPR036788 Translation initiation factor 3 (IF-3), C-terminal domain superfamily
8 183 PANTHER PTHR10938 TRANSLATION INITIATION FACTOR IF-3
8 183 InterPro IPR001288 Translation initiation factor 3
96 183 SUPERFAMILY SSF55200 Translation initiation factor IF3, C-terminal domain
96 183 InterPro IPR036788 Translation initiation factor 3 (IF-3), C-terminal domain superfamily
10 87 Gene3D G3DSA:3.10.20.80 -
10 87 InterPro IPR036787 Translation initiation factor 3 (IF-3), N-terminal domain superfamily
96 180 Pfam PF00707 Translation initiation factor IF-3, C-terminal domain
96 180 InterPro IPR019815 Translation initiation factor 3, C-terminal
15 182 NCBIfam TIGR00168 translation initiation factor IF-3
15 182 InterPro IPR001288 Translation initiation factor 3
88 183 FunFam G3DSA:3.30.110.10:FF:000001 Translation initiation factor IF-3

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2743
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.449

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
A
5LMO
Q5SKU2 347.2 Da LogP -1.86 TPSA 186.1 ✓ Ro5 ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
PBM
1TIF
P03000 252.3 Da LogP 1.37 TPSA 0.0 ✓ Ro5 ✓ Clean C[Pb+](C)C
U
5LMO
Q5SKU2 324.2 Da LogP -2.73 TPSA 171.3 ✓ Ro5 ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.