Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2755
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2755 eco
Status: annotated
Amino acids: 156
Structure source: AlphaFold

GO

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0004867 Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.546

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
GO:0004867 Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
100	155	Gene3D	G3DSA:4.10.1230.10	Ecotin, trypsin inhibitor
100	155	InterPro	IPR027438	Ecotin, C-terminal
20	155	CDD	cd00242	Ecotin
20	155	InterPro	IPR023084	Proteinase inhibitor I11, ecotin, gammaproteobacteria
1	19	Phobius	SIGNAL_PEPTIDE	Signal peptide region
17	99	Gene3D	G3DSA:2.60.40.550	Ecotin
1	19	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
26	146	Pfam	PF03974	Ecotin
26	146	InterPro	IPR005658	Proteinase inhibitor I11, ecotin
1	156	PIRSF	PIRSF006865	Ecotin
1	156	InterPro	IPR005658	Proteinase inhibitor I11, ecotin
23	154	SUPERFAMILY	SSF49772	Ecotin, trypsin inhibitor
23	154	InterPro	IPR036198	Ecotin superfamily
20	156	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	19	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
18	155	PANTHER	PTHR35890	-
18	155	InterPro	IPR005658	Proteinase inhibitor I11, ecotin
3	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	156	Hamap	MF_00706	Ecotin [eco].
1	156	InterPro	IPR023084	Proteinase inhibitor I11, ecotin, gammaproteobacteria
15	19	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2755	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.546

PA2755