Protein profile

PA2761

hypothetical protein

Genome: NC_002516.2

Gene: PA2761 Structure source: AlphaFold UniProt Q9I082

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Amino acids 138

Annotations 2

Features 7

PDB binders 0

Druggability 0.775

Overview

Basic information about this protein and its source genome.

Accession: PA2761
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2761
Status: annotated
Amino acids: 138
Structure source: AlphaFold

GO:0031459 Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). GO:1901053 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sarcosine.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.775

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0031459 Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).
GO:1901053 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sarcosine.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records

Show feature table

Start	End	DB	Term	Name
1	43	Phobius	SIGNAL_PEPTIDE	Signal peptide region
21	43	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	38	SignalP_EUK	SignalP-noTM	SignalP-noTM
34	43	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
44	138	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	21	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
22	33	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2761	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.775