Protein profile

PA2766

transcriptional regulator

Genome: NC_002516.2

Gene: PA2766 Structure source: AlphaFold UniProt Q9I077
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Amino acids 193
Annotations 1
Features 16
PDB binders 0
Druggability 0.914

Overview

Basic information about this protein and its source genome.

Accession
PA2766
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2766
Status
annotated
Amino acids
193
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.914
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
76 174 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
76 174 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
15 61 Pfam PF00440 Bacterial regulatory proteins, tetR family
15 61 InterPro IPR001647 DNA-binding HTH domain, TetR-type
118 138 Coils Coil Coil
52 175 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
9 69 ProSiteProfiles PS50977 TetR-type HTH domain profile.
9 69 InterPro IPR001647 DNA-binding HTH domain, TetR-type
6 178 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
5 51 Gene3D G3DSA:1.10.10.60 -
1 71 SUPERFAMILY SSF46689 Homeodomain-like
1 71 InterPro IPR009057 Homeobox-like domain superfamily
15 28 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
15 28 InterPro IPR001647 DNA-binding HTH domain, TetR-type
36 59 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
36 59 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2766
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.914