Protein profile

PA2777

hypothetical protein

Genome: NC_002516.2

Gene: PA2777 Structure source: AlphaFold UniProt Q9I066
Export view
Amino acids 318
Annotations 6
Features 28
PDB binders 2
Druggability 0.684

Overview

Basic information about this protein and its source genome.

Accession
PA2777
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2777
Status
annotated
Amino acids
318
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015499 Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. GO:0015724 The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.684
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MANDKRTSPPTPRQPAKGGAAGKRQGHAAEGTRKPRARGEERKEKPADGRSATALTANERREIDDKQPPRAAVLHEVIRVQGEHELQRTLAALWWSAVAAGLTIGLSLMGMGLFRAALPEQEWAIIVSSFGYPMGFLAVILARQQLFTENTLTAVLPVMTEPTLEKAWQLLRLWSVVLFGNIVGTLLFAWAVLHLPIFNEAADAAFLEIGREVMHNDLAQMFAKGIVSGWMIATMVWLIPAAEGAKIWIIAMVTYLMALGSFTHIVVGSAEVGYLAFAGEIGWAEFLLKFALPTLGGNIVGGSLIFALISHAQIRSEG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015499 Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.
  • GO:0015724 The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
77 310 Pfam PF01226 Formate/nitrite transporter
77 310 InterPro IPR000292 Formate/nitrite transporter
123 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
65 304 Gene3D G3DSA:1.20.1080.10 Glycerol uptake facilitator protein.
65 304 InterPro IPR023271 Aquaporin-like
1 68 MobiDBLite mobidb-lite consensus disorder prediction
92 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
218 240 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 91 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
218 240 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
310 318 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
268 286 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
176 198 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
64 316 PANTHER PTHR30520 FORMATE TRANSPORTER-RELATED
64 316 InterPro IPR000292 Formate/nitrite transporter
247 266 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 68 MobiDBLite mobidb-lite consensus disorder prediction
247 267 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
143 172 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
199 217 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118 122 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
287 309 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
67 304 FunFam G3DSA:1.20.1080.10:FF:000010 Inner membrane protein
286 308 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
241 246 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
123 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
173 198 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2777
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.684
1 0.372
2 0.273

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
HV6
7E27
O77389 312.2 Da LogP 3.22 TPSA 66.8 ✓ Ro5 ✓ Clean COc1ccc(c(c1)O)C(=O)/C=C(/C(C(F)(F)F)(F)F)\O
R7M
6VQR
O77389 312.2 Da LogP 2.55 TPSA 55.8 ✓ Ro5 ✓ Clean COc1ccc2c(c1)O[C@](CC2=O)(C(C(F)(F)F)(F)F)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.