Protein profile

PA2780

hypothetical protein

Genome: NC_002516.2

Gene: PA2780 Structure source: Experimental + AlphaFold UniProt Q9I063
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Amino acids 114
Annotations 8
Features 12
PDB binders 0
Druggability 0.355

Overview

Basic information about this protein and its source genome.

Accession
PA2780
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2780
Status
annotated
Amino acids
114
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:2000146 Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.355
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:2000146 Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:1900192 Any process that activates or increases the frequency, rate or extent of single-species biofilm formation.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
2 61 Pfam PF13560 Helix-turn-helix domain
1 101 Gene3D G3DSA:1.10.260.40 -
1 101 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
1 101 FunFam G3DSA:1.10.260.40:FF:000059 Transcriptional regulator
5 64 SMART SM00530 mbf_short4
5 64 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
3 64 CDD cd00093 HTH_XRE
3 64 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
6 64 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
6 64 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 70 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
1 70 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4O8B
X-ray 2.30 Å A
100.0% 1-114
PDBe RCSB PDBj File
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AlphaFold PA2780
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.355