Protein profile

PA2788

chemotaxis transducer

Genome: NC_002516.2

Gene: PA2788 mcpN Structure source: Experimental + AlphaFold UniProt Q9I055
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Amino acids 531
Annotations 4
Features 26
PDB binders 0
Druggability 0.822

Overview

Basic information about this protein and its source genome.

Accession
PA2788
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2788 mcpN
Status
annotated
Amino acids
531
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.822
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
266 530 SMART SM00283 MA_2
266 530 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
253 273 Coils Coil Coil
178 198 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
46 177 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
446 508 ProSiteProfiles PS50192 t-SNARE coiled-coil homology domain profile.
446 508 InterPro IPR000727 Target SNARE coiled-coil homology domain
23 530 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
332 497 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
332 497 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
459 479 Coils Coil Coil
199 531 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
202 531 Gene3D G3DSA:1.10.287.950 -
21 45 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
178 200 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
230 530 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
201 531 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
259 495 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
259 495 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
296 495 CDD cd11386 MCP_signal
52 140 Pfam PF13675 Type IV pili methyl-accepting chemotaxis transducer N-term
52 140 InterPro IPR029095 NarX-like, N-terminal
201 254 ProSiteProfiles PS50885 HAMP domain profile.
201 254 InterPro IPR003660 HAMP domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6GCV
X-ray 1.30 Å A,B,C
25.6% 44-179
PDBe RCSB PDBj File
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AlphaFold PA2788
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.822
1 0.776

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.44 0.066