Protein profile

PA2801

hypothetical protein

Genome: NC_002516.2

Gene: PA2801 Structure source: Experimental + AlphaFold UniProt Q9I042
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Amino acids 134
Annotations 1
Features 6
PDB binders 0
Druggability 0.79

Overview

Basic information about this protein and its source genome.

Accession
PA2801
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2801
Status
annotated
Amino acids
134
Structure source
Experimental + AlphaFold
GO
GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.79
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
9 132 PANTHER PTHR31793 4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER
14 133 Pfam PF13279 Thioesterase-like superfamily
5 133 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
5 133 InterPro IPR029069 HotDog domain superfamily
5 134 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
8 115 CDD cd00586 4HBT

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3QY3
X-ray 1.75 Å A
100.0% 1-134
PDBe RCSB PDBj File
Viewing
AlphaFold PA2801
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.79
1 0.754

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.29 0.013