Protein profile

PA2825

transcriptional regulator

Genome: NC_002516.2

Gene: ospR PA2825 Structure source: AlphaFold UniProt Q9I018
Export view
Amino acids 163
Annotations 7
Features 13
PDB binders 2
Druggability 0.797

Overview

Basic information about this protein and its source genome.

Accession
PA2825
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ospR PA2825
Status
annotated
Amino acids
163
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. GO:1900407 Any process that modulates the frequency, rate or extent of cellular response to oxidative stress. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.797
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
  • GO:1900407 Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
47 110 Pfam PF01047 MarR family
47 110 InterPro IPR000835 MarR-type HTH domain
40 143 SMART SM00347 marrlong4
40 143 InterPro IPR000835 MarR-type HTH domain
15 155 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
15 155 InterPro IPR036390 Winged helix DNA-binding domain superfamily
20 155 ProSiteProfiles PS50995 MarR-type HTH domain profile.
20 155 InterPro IPR000835 MarR-type HTH domain
13 158 FunFam G3DSA:1.10.10.10:FF:000163 MarR family transcriptional regulator
21 156 PANTHER PTHR33164 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
21 156 InterPro IPR039422 Transcription regulators MarR/SlyA-like
13 157 Gene3D G3DSA:1.10.10.10 -
13 157 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2825
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.797
8 0.574

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4HP
5AIP
Q7DD70 152.1 Da LogP 1.02 TPSA 57.5 ✓ Ro5 ✓ Clean c1cc(ccc1CC(=O)O)O
BT6
3HSR
A0A0H3KA72 110.2 Da LogP 1.98 TPSA 0.0 ✓ Ro5 ✓ Clean c1ccc(cc1)S

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.