Protein profile

PA2831

hypothetical protein

Genome: NC_002516.2

Gene: PA2831 Structure source: Experimental + AlphaFold UniProt Q9I012
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Amino acids 375
Annotations 6
Features 9
PDB binders 2
Druggability 0.472

Overview

Basic information about this protein and its source genome.

Accession
PA2831
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2831
Status
annotated
Amino acids
375
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015630 The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. GO:0004181 Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0015631 Binding to monomeric or multimeric forms of tubulin, including microtubules. GO:0008270 Binding to a zinc ion (Zn). GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.558
Human E-value
4.74e-10
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.472
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0015630 The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
  • GO:0004181 Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0015631 Binding to monomeric or multimeric forms of tubulin, including microtubules.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
134 339 Pfam PF00246 Zinc carboxypeptidase
134 339 InterPro IPR000834 Peptidase M14, carboxypeptidase A
3 110 Pfam PF18027 Cytosolic carboxypeptidase N-terminal domain
3 110 InterPro IPR040626 Cytosolic carboxypeptidase, N-terminal
113 367 CDD cd06234 M14_PaCCP-like
107 373 SUPERFAMILY SSF53187 Zn-dependent exopeptidases
2 113 Gene3D G3DSA:2.60.40.3120 -
3 296 PANTHER PTHR12756 CYTOSOLIC CARBOXYPEPTIDASE
114 375 Gene3D G3DSA:3.40.630.10 Zn peptidases

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4A37
X-ray 1.60 Å A,B
100.0% 1-375
PDBe RCSB PDBj File
Viewing
PDB 4A39
X-ray 1.60 Å A,B
100.0% 1-375
PDBe RCSB PDBj File
Loaded
PDB 4A38
X-ray 2.00 Å A,B
100.0% 1-375
PDBe RCSB PDBj File
Loaded
AlphaFold PA2831
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.412
2 0.409
3 0.231

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 26.8 0.917
2 24.88 0.902
3 8.56 0.457
4 7.79 0.413
5 4.82 0.215

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
BZS
4A38 2.00 Å Open crystal
208.2 Da LogP 1.40 TPSA 74.6 ✓ Ro5 ✓ Clean c1ccc(cc1)C[C@H](CC(=O)O)C(=O)O
GEM
4A39 1.60 Å Open crystal
235.3 Da LogP -0.87 TPSA 136.5 ✓ Ro5 ✓ Clean C(CS[C@@H](CC(=O)O)C(=O)O)NC(=N)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.