Protein profile

PA2836

secretion protein

Genome: NC_002516.2

Gene: PA2836 Structure source: AlphaFold UniProt Q9I007
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Amino acids 354
Annotations 1
Features 21
PDB binders 0
Druggability 0.845

Overview

Basic information about this protein and its source genome.

Accession
PA2836
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2836
Status
annotated
Amino acids
354
Structure source
AlphaFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.845
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
115 181 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
81 114 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
47 290 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
47 290 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
31 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
87 135 Coils Coil Coil
330 345 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
58 78 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
11 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
183 305 SUPERFAMILY SSF111369 HlyD-like secretion proteins
153 173 Coils Coil Coil
227 349 Gene3D G3DSA:2.40.30.170 -
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 346 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
291 342 Pfam PF00529 Cation efflux system protein CusB domain 1
291 342 InterPro IPR043602 Cation efflux system protein CusB, domain 1
50 80 Gene3D G3DSA:2.40.50.100 -
38 354 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
50 128 SUPERFAMILY SSF111369 HlyD-like secretion proteins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2836
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.845
2 0.842