Protein profile

PA2843

aldolase

Genome: NC_002516.2

Gene: PA2843 Structure source: Experimental + AlphaFold UniProt Q9I000
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Amino acids 448
Annotations 4
Features 9
PDB binders 8
Druggability 0.804

Overview

Basic information about this protein and its source genome.

Accession
PA2843
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2843
Status
annotated
Amino acids
448
Structure source
Experimental + AlphaFold
EC
2.5.1.54
GO
GO:0003849 Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0009073 The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0002047 The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.804
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0003849 Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.
  • GO:0009073 The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
  • GO:0002047 The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
2 444 SUPERFAMILY SSF51569 Aldolase
2 447 PANTHER PTHR21337 PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2
2 447 InterPro IPR002480 DAHP synthetase, class II
177 445 Gene3D G3DSA:3.20.20.70 Aldolase class I
177 445 InterPro IPR013785 Aldolase-type TIM barrel
5 447 NCBIfam TIGR01358 3-deoxy-7-phosphoheptulonate synthase class II
5 447 InterPro IPR002480 DAHP synthetase, class II
5 440 Pfam PF01474 Class-II DAHP synthetase family
5 440 InterPro IPR002480 DAHP synthetase, class II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5UXM
X-ray 1.54 Å A
99.8% 2-448
PDBe RCSB PDBj File
Viewing
PDB 5UXN
X-ray 2.20 Å A
99.8% 2-448
PDBe RCSB PDBj File
Loaded
PDB 5UXO
X-ray 2.35 Å A
99.8% 2-448
PDBe RCSB PDBj File
Loaded
AlphaFold PA2843
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.804
4 0.421
2 0.31

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.97 0.933
2 9.86 0.53
3 2.58 0.073
4 1.24 0.012
5 0.99 0.005

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

58 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
PEP
5UXM 1.54 Å Open crystal
168.0 Da LogP -0.31 TPSA 104.1 ✓ Ro5 ✓ Clean C=C(C(=O)O)OP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.