Protein profile

PA2849

transcriptional regulator

Genome: NC_002516.2

Gene: ohrR PA2849 Structure source: AlphaFold UniProt Q9HZZ4
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Amino acids 151
Annotations 9
Features 19
PDB binders 5
Druggability 0.941

Overview

Basic information about this protein and its source genome.

Accession
PA2849
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ohrR PA2849
Status
annotated
Amino acids
151
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:1900407 Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.941
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:1900407 Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
13 119 PANTHER PTHR33164 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
13 119 InterPro IPR039422 Transcription regulators MarR/SlyA-like
42 100 Pfam PF01047 MarR family
42 100 InterPro IPR000835 MarR-type HTH domain
35 133 SMART SM00347 marrlong4
35 133 InterPro IPR000835 MarR-type HTH domain
59 75 PRINTS PR00598 Bacterial regulatory protein MarR family signature
59 75 InterPro IPR000835 MarR-type HTH domain
95 111 PRINTS PR00598 Bacterial regulatory protein MarR family signature
95 111 InterPro IPR000835 MarR-type HTH domain
76 91 PRINTS PR00598 Bacterial regulatory protein MarR family signature
76 91 InterPro IPR000835 MarR-type HTH domain
8 149 FunFam G3DSA:1.10.10.10:FF:000163 MarR family transcriptional regulator
7 149 Gene3D G3DSA:1.10.10.10 -
7 149 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
8 148 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
8 148 InterPro IPR036390 Winged helix DNA-binding domain superfamily
15 142 ProSiteProfiles PS50995 MarR-type HTH domain profile.
15 142 InterPro IPR000835 MarR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2849
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.941

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4HP
5AIP
Q7DD70 152.1 Da LogP 1.02 TPSA 57.5 ✓ Ro5 ✓ Clean c1cc(ccc1CC(=O)O)O
BHA
5X7Z
P9WME9 153.1 Da LogP 0.67 TPSA 83.5 ✓ Ro5 ✓ Clean c1cc(c(cc1N)O)C(=O)O
BT6
3HSR
A0A0H3KA72 110.2 Da LogP 1.98 TPSA 0.0 ✓ Ro5 ✓ Clean c1ccc(cc1)S
SAL
5X80
P9WME9 138.1 Da LogP 1.09 TPSA 57.5 ✓ Ro5 ✓ Clean c1ccc(c(c1)C(=O)O)O
WCA
6C28
Q6N8V9 913.7 Da LogP 0.08 TPSA 383.9 3 viol. ✓ Clean CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.