Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2854
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2854
Status: annotated
Amino acids: 323
Structure source: AlphaFold

GO

GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0071972 Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0018104 The process of covalently linking peptidoglycan (murein) to proteins. GO:0008360 Any process that modulates the surface configuration of a cell. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.598

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MLSRVPVVSLSFAALLSAGSASALELQLPPPGEDVVGQVQVIKAKYEDTFADLGEQYNLGYSEMVAANPGVDPWLPGVGTEVIIPTRFVLPPGPREGVVINLAEYRLYYYPKGQNVVHTYPLGIGREGWGSPIANTRITAKTKDPAWYPPASIRAEHAADGDPLPTVVPPGPDNPLGPYKLTLGVPGYLIHGSNKKFGIGTRTSHGCFRMYNADVTHLFSMISVGTSVRIINEPYKFGVSNGKVYLEAHTPLNDHGDPSVVDKHTAVINTLLKRDDLAKRIQLNWDVVREVVASEDGVPVEIAQESAPAMTATVDSDPTQLTP

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
GO:0071972 Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine.
GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
GO:0018104 The process of covalently linking peptidoglycan (murein) to proteins.
GO:0008360 Any process that modulates the surface configuration of a cell.
GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
98	230	Pfam	PF03734	L,D-transpeptidase catalytic domain
98	230	InterPro	IPR005490	L,D-transpeptidase catalytic domain
24	323	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	23	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	23	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
98	231	CDD	cd16913	YkuD_like
98	231	InterPro	IPR005490	L,D-transpeptidase catalytic domain
4	240	PANTHER	PTHR30582	L,D-TRANSPEPTIDASE
48	84	CDD	cd00118	LysM
48	84	InterPro	IPR018392	LysM domain
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
96	230	SUPERFAMILY	SSF141523	L,D-transpeptidase catalytic domain-like
96	230	InterPro	IPR038063	L,D-transpeptidase catalytic domain-like
7	18	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
95	231	Gene3D	G3DSA:2.40.440.10	-
95	231	InterPro	IPR038063	L,D-transpeptidase catalytic domain-like
19	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2854	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.598
3				0.255

PA2854