Protein profile

PA2856

esterase TesA

Genome: NC_002516.2

Gene: PA2856 tesA Structure source: Experimental + AlphaFold UniProt Q9HZY8
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Amino acids 201
Annotations 5
Features 15
PDB binders 1
Druggability 0.778

Overview

Basic information about this protein and its source genome.

Accession
PA2856
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2856 tesA
Status
annotated
Amino acids
201
Structure source
Experimental + AlphaFold
EC
3.1.1.1
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0004064 Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. GO:0106435 Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. GO:0004622 Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.778
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0004064 Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.
  • GO:0106435 Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.
  • GO:0004622 Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
26 181 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family
26 181 InterPro IPR013830 SGNH hydrolase-type esterase domain
22 201 Gene3D G3DSA:3.40.50.1110 SGNH hydrolase
22 201 InterPro IPR036514 SGNH hydrolase superfamily
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
23 196 PANTHER PTHR30383 THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1
22 201 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
23 198 CDD cd01822 Lysophospholipase_L1_like
23 200 SUPERFAMILY SSF52266 SGNH hydrolase
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
3 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
18 201 FunFam G3DSA:3.40.50.1110:FF:000001 Multifunctional acyl-CoA thioesterase I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4JGG
X-ray 1.90 Å A,B
100.0% 1-201
PDBe RCSB PDBj File
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AlphaFold PA2856
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.778
2 0.406

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.65 0.338
2 0.92 0.004

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
OCA
1U8U
P0ADA1 144.2 Da LogP 2.43 TPSA 37.3 ✓ Ro5 ✓ Clean CCCCCCCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.