Protein profile

PA2858

hypothetical protein

Genome: NC_002516.2

Gene: PA2858 Structure source: AlphaFold UniProt Q9HZY6
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Amino acids 830
Annotations 1
Features 33
PDB binders 0
Druggability 0.891

Overview

Basic information about this protein and its source genome.

Accession
PA2858
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2858
Status
annotated
Amino acids
830
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.891
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
794 815 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
490 706 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
442 461 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
467 489 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
395 414 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
283 302 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
418 441 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
395 412 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
728 758 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
413 417 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
792 814 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
760 782 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 283 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 829 PANTHER PTHR30287 MEMBRANE COMPONENT OF PREDICTED ABC SUPERFAMILY METABOLITE UPTAKE TRANSPORTER
7 829 InterPro IPR038766 Membrane component of ABC transporter, predicted
303 328 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
816 830 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
462 489 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 260 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
329 347 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
783 793 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
304 326 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
348 374 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
352 374 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
705 727 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 282 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
419 441 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
707 727 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
759 782 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
375 394 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2858
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.891
2 0.26