Protein profile

PA2862

lactonizing lipase

Genome: NC_002516.2

Gene: PA2862 lip lipA Structure source: Experimental + AlphaFold UniProt P26876
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Amino acids 311
Annotations 8
Features 15
PDB binders 8
Druggability 0.893

Overview

Basic information about this protein and its source genome.

Accession
PA2862
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2862 lip lipA
Status
annotated
Amino acids
311
Structure source
Experimental + AlphaFold
EC
3.1.1.3
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016298 Catalysis of the hydrolysis of a lipid. GO:0046872 Binding to a metal ion. GO:0004806 Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+. GO:0016042 The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.893
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0016298 Catalysis of the hydrolysis of a lipid.
  • GO:0046872 Binding to a metal ion.
  • GO:0004806 Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+.
  • GO:0016042 The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
  • GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 280 Pfam PF00561 alpha/beta hydrolase fold
35 280 InterPro IPR000073 Alpha/beta hydrolase fold-1
27 311 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
27 311 FunFam G3DSA:3.40.50.1820:FF:000229 Lactonizing lipase
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
19 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
29 307 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
29 307 InterPro IPR029058 Alpha/Beta hydrolase fold
6 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
27 311 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
27 311 InterPro IPR029058 Alpha/Beta hydrolase fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1EX9
X-ray 2.54 Å A
91.6% 27-311
PDBe RCSB PDBj File
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AlphaFold PA2862
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.893
6 0.785

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.1 0.918
2 3.73 0.143
3 1.1 0.007

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

58 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
OCP
1EX9 2.54 Å Open crystal
578.8 Da LogP 8.09 TPSA 123.2 2 viol. ✓ Clean CCCCCCCCNC(=O)OC[C@H](CO[P@](=O)(CCCCCCCC)O)OC(…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.