Protein profile

PA2900

hypothetical protein

Genome: NC_002516.2

Gene: PA2900 Structure source: AlphaFold UniProt Q9HZU7
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Amino acids 269
Annotations 4
Features 32
PDB binders 7
Druggability 0.55

Overview

Basic information about this protein and its source genome.

Accession
PA2900
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2900
Status
annotated
Amino acids
269
Structure source
AlphaFold
GO
GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.55
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
145 262 ProSiteProfiles PS51123 OmpA-like domain profile.
145 262 InterPro IPR006665 OmpA-like domain
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
59 262 PANTHER PTHR30329 STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX
97 124 Coils Coil Coil
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
21 269 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101 264 Gene3D G3DSA:3.30.1330.60 -
101 264 InterPro IPR036737 OmpA-like domain superfamily
155 258 CDD cd07185 OmpA_C-like
155 258 InterPro IPR006665 OmpA-like domain
157 252 Pfam PF00691 OmpA family
157 252 InterPro IPR006665 OmpA-like domain
203 219 PRINTS PR01021 OMPA domain signature
203 219 InterPro IPR006664 Outer membrane protein, bacterial
158 180 PRINTS PR01021 OMPA domain signature
158 180 InterPro IPR006664 Outer membrane protein, bacterial
188 203 PRINTS PR01021 OMPA domain signature
188 203 InterPro IPR006664 Outer membrane protein, bacterial
30 50 Coils Coil Coil
241 261 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature
221 240 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature
203 220 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature
29 104 Pfam PF14346 Domain of unknown function (DUF4398)
29 104 InterPro IPR025511 Domain of unknown function DUF4398
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 18 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
149 258 SUPERFAMILY SSF103088 OmpA-like
149 258 InterPro IPR036737 OmpA-like domain superfamily
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2900
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.55
2 0.226

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
5GP
5Y61
Q9I4L6 363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
7QA
5U1H
P13794 305.3 Da LogP -1.21 TPSA 179.0 1 viol. ✓ Clean C[C@H](C(=O)O)NC(=O)[C@H](CCC[C@H](C(=O)O)N)NC(…
API
5LKW
B4EDC1 190.2 Da LogP -1.02 TPSA 126.6 ✓ Ro5 ✓ Clean C(C[C@H](C(=O)O)N)C[C@@H](C(=O)O)N
C8E
4RLC
P13794 306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO
CXS
5N2C
B4EDC1 221.3 Da LogP 1.19 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCCS(=O)(=O)O
OXL
5N2C
B4EDC1 88.0 Da LogP -3.51 TPSA 80.3 ✓ Ro5 ✓ Clean C(=O)(C(=O)[O-])[O-]
SRT
4G88
Q6RYW5 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.