Protein profile

PA2903

precorrin-3 methylase CobJ

Genome: NC_002516.2

Gene: PA2903 cobJ Structure source: AlphaFold UniProt Q9HZU4

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Amino acids 559

Annotations 3

Features 17

PDB binders 0

Druggability 0.782

Overview

Basic information about this protein and its source genome.

Accession: PA2903
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2903 cobJ
Status: annotated
Amino acids: 559
Structure source: AlphaFold

GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.782

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
307	556	SUPERFAMILY	SSF53790	Tetrapyrrole methylase
307	556	InterPro	IPR035996	Tetrapyrrole methylase superfamily
300	558	PANTHER	PTHR47036	COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED
7	212	SUPERFAMILY	SSF159672	CbiG N-terminal domain-like
7	212	InterPro	IPR038029	GbiG N-terminal domain superfamily
310	556	NCBIfam	TIGR01466	precorrin-3B C(17)-methyltransferase
310	556	InterPro	IPR006363	Precorrin-3B C17-methyltransferase domain
310	556	CDD	cd11646	Precorrin_3B_C17_MT
423	557	Gene3D	G3DSA:3.30.950.10	-
423	557	InterPro	IPR014776	Tetrapyrrole methylase, subdomain 2
309	520	Pfam	PF00590	Tetrapyrrole (Corrin/Porphyrin) Methylases
309	520	InterPro	IPR000878	Tetrapyrrole methylase
302	422	Gene3D	G3DSA:3.40.1010.10	-
302	422	InterPro	IPR014777	Tetrapyrrole methylase, subdomain 1
2	126	Gene3D	G3DSA:3.40.50.11220	-
52	130	Pfam	PF11760	Cobalamin synthesis G N-terminal
52	130	InterPro	IPR021744	Cobalamin synthesis G, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2903	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.782