Protein profile

PA2904

precorrin-2 C(20)-methyltransferase

Genome: NC_002516.2

Gene: PA2904 cobI Structure source: AlphaFold UniProt Q9HZU3
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Amino acids 250
Annotations 6
Features 15
PDB binders 0
Druggability 0.848

Overview

Basic information about this protein and its source genome.

Accession
PA2904
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2904 cobI
Status
annotated
Amino acids
250
Structure source
AlphaFold
EC
2.1.1.130
GO
GO:0030788 Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.848
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0030788 Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
140 245 Gene3D G3DSA:3.30.950.10 -
140 245 InterPro IPR014776 Tetrapyrrole methylase, subdomain 2
2 240 SUPERFAMILY SSF53790 Tetrapyrrole methylase
2 240 InterPro IPR035996 Tetrapyrrole methylase superfamily
7 138 Gene3D G3DSA:3.40.1010.10 -
7 138 InterPro IPR014777 Tetrapyrrole methylase, subdomain 1
9 220 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases
9 220 InterPro IPR000878 Tetrapyrrole methylase
13 239 CDD cd11645 Precorrin_2_C20_MT
13 239 InterPro IPR012382 Precorrin-2 C(20)-methyltransferase
7 239 NCBIfam TIGR01467 precorrin-2 C(20)-methyltransferase
7 239 InterPro IPR006364 Precorrin-2 C(20)-methyltransferase domain
5 246 PIRSF PIRSF036427 Precrrn-2_mtase
5 246 InterPro IPR012382 Precorrin-2 C(20)-methyltransferase
7 246 PANTHER PTHR43467 COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2904
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.848