Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2907
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cobL PA2907
Status: annotated
Amino acids: 415
Structure source: AlphaFold

EC

2.1.1.132

GO

GO:0046025 Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.764

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

2.1.1.132

Gene Ontology (GO)

5

GO:0046025 Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2.
GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
GO:0032259 The process in which a methyl group is covalently attached to a molecule.
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
211	385	SUPERFAMILY	SSF53335	S-adenosyl-L-methionine-dependent methyltransferases
211	385	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
9	406	PANTHER	PTHR43182	COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING)
10	210	SUPERFAMILY	SSF53790	Tetrapyrrole methylase
10	210	InterPro	IPR035996	Tetrapyrrole methylase superfamily
7	407	PIRSF	PIRSF036428	CobL_MTase
7	407	InterPro	IPR006365	Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase
219	410	Gene3D	G3DSA:3.40.50.150	Vaccinia Virus protein VP39
219	410	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
236	357	NCBIfam	TIGR02469	precorrin-6Y C5,15-methyltransferase (decarboxylating) subunit CbiT
236	357	InterPro	IPR014008	Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit
10	108	Gene3D	G3DSA:3.40.1010.10	-
10	108	InterPro	IPR014777	Tetrapyrrole methylase, subdomain 1
13	198	NCBIfam	TIGR02467	precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE
13	198	InterPro	IPR012818	Precorrin-6Y methyltransferase
14	210	CDD	cd11644	Precorrin-6Y-MT
14	210	InterPro	IPR012818	Precorrin-6Y methyltransferase
258	352	CDD	cd02440	AdoMet_MTases
11	191	Pfam	PF00590	Tetrapyrrole (Corrin/Porphyrin) Methylases
11	191	InterPro	IPR000878	Tetrapyrrole methylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2907	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.764
1				0.313

PA2907