Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2910
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2910 mntP
Status: annotated
Amino acids: 189
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384 Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. GO:0030026 A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell. GO:0140048 The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.778

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005384 Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
GO:0030026 A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell.
GO:0140048 The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
86	104	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
128	132	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	12	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
31	182	Pfam	PF02659	Putative manganese efflux pump
31	182	InterPro	IPR003810	Putative manganese efflux pump
1	19	Phobius	SIGNAL_PEPTIDE	Signal peptide region
168	187	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	3	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
106	128	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	19	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
13	19	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
68	85	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
36	58	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
68	85	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	185	Hamap	MF_01521	Probable manganese efflux pump MntP [mntP].
1	185	InterPro	IPR022929	Putative manganese efflux pump MntP
133	155	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
166	183	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
133	154	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
184	189	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
155	165	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20	67	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	23	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
105	127	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	185	PANTHER	PTHR35529	MANGANESE EFFLUX PUMP MNTP-RELATED
1	185	InterPro	IPR003810	Putative manganese efflux pump

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2910	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.778
3				0.317

PA2910