Protein profile

PA2920

chemotaxis transducer

Genome: NC_002516.2

Gene: PA2920 Structure source: AlphaFold UniProt Q9HZS7
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Amino acids 545
Annotations 5
Features 40
PDB binders 1
Druggability 0.886

Overview

Basic information about this protein and its source genome.

Accession
PA2920
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2920
Status
annotated
Amino acids
545
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.886
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
161 181 Coils Coil Coil
195 216 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
273 509 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
273 509 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
328 511 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
328 511 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
16 544 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
217 263 CDD cd06225 HAMP
217 545 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
214 545 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
236 545 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
216 264 Pfam PF00672 HAMP domain
216 264 InterPro IPR003660 HAMP domain
215 545 Gene3D G3DSA:1.10.287.950 -
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region
214 268 ProSiteProfiles PS50885 HAMP domain profile.
214 268 InterPro IPR003660 HAMP domain
28 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
310 509 CDD cd11386 MCP_signal
351 371 Coils Coil Coil
14 27 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 184 Pfam PF12729 Four helix bundle sensory module for signal transduction
7 184 InterPro IPR024478 Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain
33 194 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
269 544 SMART SM00283 MA_2
269 544 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
214 268 SMART SM00304 HAMP_11
433 492 SMART SM00304 HAMP_11
433 492 InterPro IPR003660 HAMP domain
195 217 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
304 333 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
304 333 InterPro IPR004090 Chemotaxis methyl-accepting receptor
381 408 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
381 408 InterPro IPR004090 Chemotaxis methyl-accepting receptor
21 46 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
21 46 InterPro IPR004090 Chemotaxis methyl-accepting receptor
410 439 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
410 439 InterPro IPR004090 Chemotaxis methyl-accepting receptor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2920
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.886
14 0.266

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
PHN
1LIH
P02941 180.2 Da LogP 2.78 TPSA 25.8 ✓ Ro5 ✓ Clean c1cc2ccc3cccnc3c2nc1

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.