Protein profile

PA2921

transcriptional regulator

Genome: NC_002516.2

Gene: PA2921 Structure source: AlphaFold UniProt Q9HZS6
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Amino acids 329
Annotations 4
Features 19
PDB binders 7
Druggability 0.85

Overview

Basic information about this protein and its source genome.

Accession
PA2921
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2921
Status
annotated
Amino acids
329
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.85
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
13 70 ProSiteProfiles PS50931 LysR-type HTH domain profile.
13 70 InterPro IPR000847 Transcription regulator HTH, LysR
15 74 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
15 74 InterPro IPR000847 Transcription regulator HTH, LysR
13 101 Gene3D G3DSA:1.10.10.10 -
13 101 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
51 62 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
51 62 InterPro IPR000847 Transcription regulator HTH, LysR
41 51 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
41 51 InterPro IPR000847 Transcription regulator HTH, LysR
30 41 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
30 41 InterPro IPR000847 Transcription regulator HTH, LysR
12 122 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
12 122 InterPro IPR036390 Winged helix DNA-binding domain superfamily
105 315 Gene3D G3DSA:3.40.190.290 -
12 312 PANTHER PTHR30419 HTH-TYPE TRANSCRIPTIONAL REGULATOR YBHD
99 306 Pfam PF03466 LysR substrate binding domain
99 306 InterPro IPR005119 LysR, substrate-binding
100 311 SUPERFAMILY SSF53850 Periplasmic binding protein-like II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2921
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.85
2 0.413

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
1PS
6G1B
Q8NP91 201.2 Da LogP -0.09 TPSA 61.1 ✓ Ro5 ✓ Clean c1cc[n+](cc1)CCCS(=O)(=O)[O-]
AKG
5Y2V
P73862 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
FLC
5ZZO
A0A0D1IHL7 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
FOR
6G1D
Q8NP91 30.0 Da LogP -0.18 TPSA 17.1 ✓ Ro5 ✓ Clean C=O
PEO
6G1B
Q8NP91 34.0 Da LogP 0.02 TPSA 40.5 ✓ Ro5 ✓ Clean OO
RUB
5Z49
Q9F1R2 310.1 Da LogP -2.50 TPSA 191.0 1 viol. ✓ Clean C([C@H]([C@H](C(=O)COP(=O)(O)O)O)O)OP(=O)(O)O
TSU
3FXU
P94678 172.2 Da LogP 1.24 TPSA 54.4 ✓ Ro5 ✓ Clean Cc1ccc(cc1)S(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.