Protein profile

PA2931

CifR protein

Genome: NC_002516.2

Gene: PA2931 cifR Structure source: Experimental + AlphaFold UniProt Q9HZR6
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Amino acids 196
Annotations 5
Features 11
PDB binders 1
Druggability 0.291

Overview

Basic information about this protein and its source genome.

Accession
PA2931
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2931 cifR
Status
annotated
Amino acids
196
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.291
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 69 Gene3D G3DSA:1.10.10.60 -
2 85 SUPERFAMILY SSF46689 Homeodomain-like
2 85 InterPro IPR009057 Homeobox-like domain superfamily
72 196 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
1 195 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
16 61 Pfam PF00440 Bacterial regulatory proteins, tetR family
16 61 InterPro IPR001647 DNA-binding HTH domain, TetR-type
81 196 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
81 196 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
9 69 ProSiteProfiles PS50977 TetR-type HTH domain profile.
9 69 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6NSN
X-ray 2.60 Å A,B
100.0% 1-196
PDBe RCSB PDBj File
Viewing
PDB 6NSM
X-ray 2.80 Å A,B
100.0% 1-196
PDBe RCSB PDBj File
Loaded
PDB 6NSR
X-ray 3.00 Å A,B,E
100.0% 1-196
PDBe RCSB PDBj File
Loaded
AlphaFold PA2931
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.291

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.14 0.05
2 1.38 0.017

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NPO
2I10
Q0RX74 139.1 Da LogP 1.30 TPSA 63.4 ✓ Ro5 ✓ Clean c1cc(ccc1[N+](=O)[O-])O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.